How focal therapy is selected

Focal treatment is not a shortcut around staging. It depends on accurate localisation of tumour, understanding of risk outside the visible lesion, and honest discussion of what is proven versus still evolving in the literature.

Multiparametric MRI (mpMRI)

mpMRI is a key tool in modern prostate cancer pathways. It can help with diagnosis, targeted biopsy, local staging, surveillance on active surveillance, and planning where focal therapy might be discussed.1 More accurate sampling and localisation supports the idea of treating a dominant area while leaving more of the gland intact, when the clinical picture fits.2

MRI is also used in other organs when ablation or focal strategies are planned, but the exact sequences and reporting standards differ by site and speciality.

Targeted and systematic biopsy

For the prostate, combining MRI with ultrasound to fuse images allows targeted cores from suspicious areas, often alongside systematic sampling according to unit protocol. The aim is to reduce under-diagnosis of higher-grade disease outside the index lesion.

Multidisciplinary review

Many centres discuss complex localised cancer in a multidisciplinary meeting (radiology, pathology, urology, radiation oncology). Recommendations are not binding on you, but they help ensure options are considered consistently.

  • What happens if pathology later shows more extensive disease than expected?
  • How will recurrence be detected (PSA, imaging, biopsy protocol)?
  • What are the effects on urinary and sexual function for the modality proposed?
  • What whole-gland treatments remain if focal therapy does not control the cancer?
General information only. Benefits, risks, alternatives and follow-up must be discussed with your treating specialist for your individual situation.
References
  1. Les C Thompson and Morgan R Pokorny - Multiparametric MRI in the diagnosis of prostate cancer – a generational change - Australian Family Physician - Volume 44, Issue 8, August 2015
  2. John R Heard, Aurash Naser-Tavakolian, Michael Nazmifar - Focal prostate cancer therapy in the era of multiparametric MRI: a review of options and outcomes - Prostate Cancer Prostatic Dis. 2023 Jun;26(2):218-227 - DOI: 10.1038/s41391-022-00501-0

Considering focal therapy?

You can ask for a second opinion on imaging, diagnosis and treatment options before you decide.